刘宏丽

发布者:

发布时间：2023年02月27日

浏览次数:

	刘宏丽，讲师，博士，硕士研究生导师
	科学研究方向
	1. 针对关键靶标的药物设计和发现研究
	2. 蛋白质结构功能关系研究
	联系方式
	电话：0516-83262137
	Email：hongliliu@xzhmu.edu.cn
	通讯：江苏省徐州市云龙区铜山路209号，221004

个人简历

2020.08--至今 j9老哥必备的交流社区，j9老哥必备的交流社区，讲师

2017.09-2020.06 兰州大学，j9老哥必备的交流社区，博士，导师：刘焕香

2014.09-2017.06 兰州大学，j9老哥必备的交流社区，硕士，导师：李加忠

2012.09-2014.06 长治医学院，药学系，学士

承担科研课题

1. 国家自然科学基金青年基金，22107090，具有动力学选择性的c-Src抑制剂的设计、合成及其对多囊肾抑制剂活性研究，2022.01-2024.12，30万，主持。

2. j9老哥必备的交流社区优秀人才启动基金，D2020036，磷酸化对Tau蛋白错误折叠和聚集机制的研究，2020.09-2023.08，20万，主持。

近五年代表性论文

1. Chen Mohan, Li Zheng, Sun Gang, Jin Shuang, Hao Xiyue, Zhang Chi, Liu Ling, Zhang Ling, Liu Hongli*, Xue Yunsheng*. Theoretical study on the free radical scavenging potency and mechanism of natural coumestans: Roles of substituent noncovalent interaction and solvent. Phytochemistry. 2023, 207:113580. (IF:7.741)

2. Liu Hongli, Li Qin, Xiong Chunmei, Zhong Haiyang, Zhang Qianqian, Liu Huanxiang*, Yao Xiaojun. Uncovering the effect of pS202/pT205/pS208 triple phosphorylations on the conformational features of the key fragment G192-T212 of tau protein. ACS Chemical Neuroscience, 2021, 12(6):1039-1048. (IF:4.418)

3. Liu Hongli, Zhong Haiyang, Xu Zerong, Zhang Qianqian, Shah Syed Jawad Ali, Liu Huanxiang*, Yao Xiaojun. The misfolding mechanism of the key fragment R3 of tau protein: a combined molecular dynamics simulation and markov state model study. Physical Chemistry Chemical Physics, 2020, 22(19):10968-10980. (IF:3.676)

4. Liu Hongli, Liu Xuewei, Zhou Shuangyan, An Xiaoli, Liu Huanxiang*, Yao Xiaojun. Disclosing the template-induced misfolding mechanism of tau protein by studying the dissociation of the boundary chain from the formed tau fibril based on a steered molecular dynamics simulation. ACS Chemical Neuroscience, 2019, 10(3):1854-1865. (IF:4.486)

5 Liu Hongli, Zhong Haiyang, Liu Xuewei, Zhou Shuangyan, Tan Shuoyan, Liu Huanxiang*, Yao Xiaojun. Disclosing the mechanism of spontaneous aggregation and template-induced misfolding of the key hexapeptide (PHF6) of tau protein based on molecular dynamics simulation. ACS Chemical Neuroscience, 2019, 10(12):4810-4823. (IF:4.486)